METABOLISM OF ACID MUCOPOLYSACCHARIDES IN THE SHWARTZMAN PHENOMENON
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چکیده
منابع مشابه
Metabolism of Acid Mucopolysaccharides in the Shwartzman Phenomenon
The effect of the Shwartzman phenomenon on the metabolism of the acid mucopolysaccharides (MPS), hyaluronic acid and chondroitin sulfate, from rabbits with localized lesions was studied. Quantitative changes of MPS were observed by two techniques-the in vivo incorporation of glucose C(14) into the MPS and the in vitro dilution of C(14)-labeled MPS. The results indicate an increased concentratio...
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The two-stage inflammatory state observed by Sanarelli (1) and by Shwartzman (2) is considered an interesting, although not entirely understood, reaction of tissue. The reaction localized to skin, referred to as the Shwartzman phenomenon, represents a special type of inflammatory change, one requiring "preparation" of tissue by intracutaneous injection, usually of an endotoxin from Gram-negativ...
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The Shwartzman phenomenon can be inhibited by an intravenous injection of a potent bacterial filtrate within a few hours before or after the preparatory intradermal injection. The inhibitory effect is produced non-specifically by filtrates potent in the elicitation of the Shwartzman phenomenon, and it is of a transitory nature. The relation of the observation described to anaphylactic desensiti...
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Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity. A similar modification occurs spontaneously in meningococcus culture filtrates on standing. Inasmuch as these changes parallel tho...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1960
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.112.4.713